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    HMO1 Hmo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HMO1
    Official Full Name
    Hmo1p
    Primary source
    SGD:S000002581
    Locus tag
    YDR174W
    See related
    AllianceGenome:SGD:S000002581; FungiDB:YDR174W; VEuPathDB:YDR174W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSM2
    Summary
    Enables DNA binding activity, bending; double-stranded DNA binding activity; and four-way junction DNA binding activity. Involved in several processes, including chromosome organization; regulation of DNA-templated transcription; and transcriptional start site selection at RNA polymerase II promoter. Acts upstream of or within chromatin organization. Located in cytosol; nucleus; and rDNA heterochromatin. Part of small-subunit processome. Is active in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HMO1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (812110..812850)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translation termination factor GTPase eRF3 Neighboring gene inositol polyphosphate multikinase Neighboring gene mitochondrial 37S ribosomal protein RSM24 Neighboring gene histone acetyltransferase NGG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo. Higashino A, et al. Biosci Biotechnol Biochem, 2015. PMID 25410521
    2. In vitro studies on non-canonical DNA binding specificities of KAP6 and HMO1 and mechanistic insights into DNA bound and unbinding dynamics of KAP6. Rajakumara E, et al. Int J Biol Macromol, 2020 Oct 1. PMID 32497665
    3. Yeast HMO1: Linker Histone Reinvented. Panday A, et al. Microbiol Mol Biol Rev, 2017 Mar. PMID 27903656, Free PMC Article
    4. Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo. Kasahara K, et al. Genes Cells, 2016 Dec. PMID 27860073
    5. Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Bauerle KT, et al. Biochemistry, 2006 Mar 21. PMID 16533046

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.
      Title: Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.
    2. Targeting of Hmo1 to subcompartments of the budding yeast nucleolus.
      Title: Targeting of Hmo1 to subcompartments of the budding yeast nucleolus.
    3. Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT.
      Title: Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT.
    4. Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
      Title: Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
    5. Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
      Title: Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
    6. Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae.
      Title: Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae.
    7. Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p.
      Title: DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene.
    8. HMO1 appears to have evolved a unique linker histone-like function involving the ability to stabilize both conventional nucleosome arrays as well as DNA regions characterized by low nucleosome density or the presence of noncanonical nucleosomes.
      Title: Yeast HMO1: Linker Histone Reinvented.
    9. studied the genome-wide binding patterns of Nhp6, Hmo1 and the SWI/SNF complex, finding that most of gene promoters presenting high occupancy of this complex also display high enrichment of these HMG proteins.
      Title: Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions.
    10. Hmo1p functions to control DNA end resection, thereby preventing error-prone A-EJ repair and directing repairs towards classical NHEJ. The very low efficiency of DSB repair in kuDeltahmo1Delta cells further suggests that excessive DNA resection is inhibitory for A-EJ.
      Title: Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables four-way junction DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA chromatin condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ribosomal protein gene transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of ribosomal protein gene transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Hmo1p
    NP_010459.1
    • Chromatin-associated high mobility group (HMG) family member; role in compacting, bending, bridging and looping DNA; lysine-rich CTD is essential for chromatin assembly, forming condensates with dsDNA; functionally similar to linker histone H1; rDNA-binding component regulates transcription from RNAPI promoters; regulates start site selection of ribosomal protein genes via RNAPII promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      812110..812850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180481.1 → NP_010459.1  TPA: Hmo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSF6, Q03973
      UniProtKB/TrEMBL
      A6ZYD2, B3LGA9, C7GN23, C8Z588, G2WAS2, N1PAE8
      Conserved Domains (1) summary
      COG5648
      Location:36 → 246
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03973.1

    Gene LinkOut

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