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    PST2 flavodoxin-like fold family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PST2
    Official Full Name
    flavodoxin-like fold family protein
    Primary source
    SGD:S000002439
    Locus tag
    YDR032C
    See related
    AllianceGenome:SGD:S000002439; FungiDB:YDR032C; VEuPathDB:YDR032C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within positive regulation of ferroptosis. Located in eisosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PST2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (504099..504695, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Rad28p Neighboring gene Mix14p Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mrh1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase. Koch K, et al. Biochim Biophys Acta Proteins Proteom, 2017 Aug. PMID 28499769
    2. A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae. Borklu Yucel E, et al. PLoS One, 2011. PMID 22216232, Free PMC Article
    3. Six new candidate members of the alpha/beta twisted open-sheet family detected by sequence similarity to flavodoxin. Grandori R, et al. Protein Sci, 1994 Dec. PMID 7756978, Free PMC Article
    4. Ferroptosis-protective membrane domains in quiescence. Megarioti AH, et al. Cell Rep, 2023 Dec 26. PMID 38096056
    5. Functional analysis of six ORFs from Saccharomyces cerevisiae chromosome IV: two-spored asci produced by disruptant of YDR027c and strain-dependent DNA heterogeneity around YDR036c. Aittamaa M, et al. Yeast, 2001 Jul. PMID 11447599

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)H dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)H dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of ferroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    flavodoxin-like fold family protein
    NP_010315.1
    • FMN-dependent NAD(P)H:quinone oxidoreductase; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      504099..504695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180340.1 → NP_010315.1  TPA: flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS16, Q12335
      UniProtKB/TrEMBL
      A6ZXZ4, B3LGN4, B5VFT5, C7GLW7, C8Z4V2, G2WAD7, N1P4I8
      Conserved Domains (1) summary
      cl00438
      Location:1 → 197
      FMN_red; NADPH-dependent FMN reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12335.1

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