FES1 Hsp70 nucleotide exchange factor FES1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FES1
Official Full Name: Hsp70 nucleotide exchange factor FES1
Primary source: SGD:S000000305
Locus tag: YBR101C
See related: AllianceGenome:SGD:S000000305; FungiDB:YBR101C; VEuPathDB:YBR101C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenyl-nucleotide exchange factor activity. Involved in cytoplasm protein quality control by the ubiquitin-proteasome system. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FES1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (443821..444693, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity of the yeast cytoplasmic Hsp70 nucleotide-exchange factor Fes1 is regulated by reversible methionine oxidation.
Title: Activity of the yeast cytoplasmic Hsp70 nucleotide-exchange factor Fes1 is regulated by reversible methionine oxidation.
Fes1 mutants defective in physical or functional interaction with Hsp70 retained activities that support Vid and cell wall integrity (CWI). Fes1 and the Fes1 mutants bound to the Vid substrate Fbp1 in vitro and captured Slt2, a signaling kinase that regulates CWI, from cell lysates.
Title: Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity.
the armadillo-type NEFs budding yeast Fes1 and its human homolog HspBP1 employ flexible N-terminal release domains (RDs) with substrate-mimicking properties to ensure the efficient release of persistent substrates from Hsp70
Title: Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70.
Cytosolic splice isoform of Fes1 is required for the degradation of misfolded proteins in yeast.The FES1 transcript undergoes unique 3' alternative splicing that results in two equally active isoforms with alternative C-termini.
Title: Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast.
cytosolic Hsp70 interacts with up to three types of nucleotide exchange factors (NEFs) homologous to human counterparts: Sse1/Sse2 (Heat shock protein 110 (Hsp110)), Fes1 (HspBP1), and Snl1 (Bag-1).
Title: Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.
Fes1, an Hsp70 nucleotide exchange factor of hitherto unclear physiological function, is a cytosolic triaging factor that promotes proteasomal degradation of misfolded proteins
Title: Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.
crystal structure and mechanism for Hsp70 nucleotide exchange
Title: Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasm protein quality control by the ubiquitin-proteasome system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Hsp70 nucleotide exchange factor FES1

NP_009659.3

Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for degradation; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

443821..444693 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178449.3 → NP_009659.3 TPA: Hsp70 nucleotide exchange factor FES1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009659.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQA0, P38260

UniProtKB/TrEMBL

A6ZL46, B3LN52, B5VE63, C7GUJ9, D3UEJ5, G2W9A6, N1P853

Conserved Domains (2) summary

pfam08609
Location:1 → 82

Fes1; Nucleotide exchange factor Fes1

cl11619
Location:125 → 224

SPK; Domain of unknown function (DUF545)