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    SNF8 ESCRT-II subunit protein SNF8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNF8
    Official Full Name
    ESCRT-II subunit protein SNF8
    Primary source
    SGD:S000005923
    Locus tag
    YPL002C
    See related
    AllianceGenome:SGD:S000005923; FungiDB:YPL002C; VEuPathDB:YPL002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL14; VPS22
    Summary
    Involved in ATP export; carbon catabolite repression of transcription from RNA polymerase II promoter by glucose; and protein targeting to vacuole. Part of ESCRT II complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SNF8 (SNF8 subunit of ESCRT-II). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNF8 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (553627..554328, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene lipid-binding protein LSP1 Neighboring gene Ula1p Neighboring gene histone acetyltransferase catalytic subunit HAT1 Neighboring gene citrate (Si)-synthase CIT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RILP interacts with the VPS22 component of the ESCRT-II complex. Progida C, et al. Biochem Biophys Res Commun, 2006 Sep 8. PMID 16857164
    2. Molecular analysis of the SNF8 gene of Saccharomyces cerevisiae. Yeghiayan P, et al. Yeast, 1995 Mar. PMID 7785322
    3. Polygenic Analysis in Absence of Major Effector ATF1 Unveils Novel Components in Yeast Flavor Ester Biosynthesis. Holt S, et al. mBio, 2018 Aug 28. PMID 30154260, Free PMC Article
    4. New SNF genes, GAL11 and GRR1 affect SUC2 expression in Saccharomyces cerevisiae. Vallier LG, et al. Genetics, 1991 Nov. PMID 1752413, Free PMC Article
    5. The sodium pump Ena1p provides mechanistic insight into the salt sensitivity of vacuolar protein sorting mutants. Logg K, et al. Biochim Biophys Acta, 2008 Jun. PMID 18395523

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ESCRT II complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ESCRT-II subunit protein SNF8
    NP_015323.1
    • Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      553627..554328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183816.1 → NP_015323.1  TPA: ESCRT-II subunit protein SNF8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W410, Q12483
      UniProtKB/TrEMBL
      A6ZWP4, B3LL60, B5VTF9, C7GV47, C8ZJ24, G2WPH8, N1NXE9
      Conserved Domains (1) summary
      pfam04157
      Location:4 → 214
      EAP30; EAP30/Vps36 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12483.1

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