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    ICL2 methylisocitrate lyase ICL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ICL2
    Official Full Name
    methylisocitrate lyase ICL2
    Primary source
    SGD:S000006210
    Locus tag
    YPR006C
    See related
    AllianceGenome:SGD:S000006210; FungiDB:YPR006C; VEuPathDB:YPR006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methylisocitrate lyase activity. Involved in propionate catabolic process, 2-methylcitrate cycle. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ICL2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (567269..568996, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aim45p Neighboring gene Hal1p Neighboring gene Rec8p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae. Heinisch JJ, et al. Yeast, 1996 Oct. PMID 8923733
    2. Metabolic adaptation via regulated enzyme degradation in the pathogenic yeast Candida albicans. Ting SY, et al. J Mycol Med, 2017 Mar. PMID 28041812
    3. The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. Luttik MA, et al. J Bacteriol, 2000 Dec. PMID 11092862, Free PMC Article
    4. Metabolic diversification of cells during the development of yeast colonies. Váchová L, et al. Environ Microbiol, 2009 Feb. PMID 19196279
    5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylisocitrate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylisocitrate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylisocitrate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in propionate catabolic process, 2-methylcitrate cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in propionate catabolic process, 2-methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylisocitrate lyase ICL2
    NP_015331.1
    • 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      567269..568996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184103.1 → NP_015331.1  TPA: methylisocitrate lyase ICL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W417, Q12031
      UniProtKB/TrEMBL
      B3LL67, N1P1Y9
      Conserved Domains (1) summary
      COG2224
      Location:39 → 575
      AceA; Isocitrate lyase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12031.1

    Gene LinkOut

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