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    MNN9 mannosyltransferase complex subunit MNN9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNN9
    Official Full Name
    mannosyltransferase complex subunit MNN9
    Primary source
    SGD:S000005971
    Locus tag
    YPL050C
    See related
    AllianceGenome:SGD:S000005971; FungiDB:YPL050C; VEuPathDB:YPL050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in cis-Golgi network. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNN9 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (460779..461966, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Oaz1p Neighboring gene Arf family GTPase ARL3 Neighboring gene Dig1p Neighboring gene translation elongation factor EF1B gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the Hansenula polymorpha homologue of the Saccharomyces cerevisiae MNN9 gene. Kim SY, et al. Yeast, 2001 Mar 30. PMID 11255253
    2. Contact of cis-Golgi with ER exit sites executes cargo capture and delivery from the ER. Kurokawa K, et al. Nat Commun, 2014 Apr 14. PMID 24728174, Free PMC Article
    3. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis. Striebeck A, et al. Open Biol, 2013 Sep 11. PMID 24026536, Free PMC Article
    4. Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Rodionov D, et al. Protein Expr Purif, 2009 Jul. PMID 19249370
    5. The cytoplasmic region of alpha-1,6-mannosyltransferase Mnn9p is crucial for retrograde transport from the Golgi apparatus to the endoplasmic reticulum in Saccharomyces cerevisiae. Okamoto M, et al. Eukaryot Cell, 2008 Feb. PMID 18083825, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study presents the structure of MNN9 in complex with Guanosine Diphosphate and Mn(2+).
      Title: Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis.
    2. These results provide further information on the role of M-Pol I and its subunits Mnn9 and Van1 in mannan biosynthesis.
      Title: Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannan polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mannosyltransferase complex subunit MNN9
    NP_015275.1
    • Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      460779..461966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183864.1 → NP_015275.1  TPA: mannosyltransferase complex subunit MNN9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015275.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W4, P39107
      UniProtKB/TrEMBL
      B3LL17, C8ZIX9, G2WPC8
      Conserved Domains (1) summary
      pfam03452
      Location:95 → 358
      Anp1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39107.3

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