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    PNT1 Pnt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PNT1
    Official Full Name
    Pnt1p
    Primary source
    SGD:S000005792
    Locus tag
    YOR266W
    See related
    AllianceGenome:SGD:S000005792; FungiDB:YOR266W; VEuPathDB:YOR266W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PNT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (821023..822294)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dse3p Neighboring gene Rbl2p Neighboring gene putative serine/threonine protein kinase HRK1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae. Ludewig G, et al. Antimicrob Agents Chemother, 1994 Dec. PMID 7695273, Free PMC Article
    2. Mutations affecting a yeast mitochondrial inner membrane protein, pnt1p, block export of a mitochondrially synthesized fusion protein from the matrix. He S, et al. Mol Cell Biol, 1999 Oct. PMID 10490599, Free PMC Article
    3. Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Saracco SA, et al. Mol Biol Cell, 2002 Apr. PMID 11950926, Free PMC Article
    4. Spatial orchestration of mitochondrial translation and OXPHOS complex assembly. Stoldt S, et al. Nat Cell Biol, 2018 May. PMID 29662179
    5. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane from matrix IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane from matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pnt1p
    NP_014909.3
    • Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      821023..822294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183685.3 → NP_014909.3  TPA: Pnt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014909.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2W6, P38969, Q08730
      UniProtKB/TrEMBL
      G2WND3, N1P3L4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38969.2

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