ADE2 phosphoribosylaminoimidazole carboxylase ADE2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADE2
Official Full Name: phosphoribosylaminoimidazole carboxylase ADE2
Primary source: SGD:S000005654
Locus tag: YOR128C
See related: AllianceGenome:SGD:S000005654; FungiDB:YOR128C; VEuPathDB:YOR128C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphoribosylaminoimidazole carboxylase activity. Involved in purine nucleobase metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADE2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (564476..566191, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazole carboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazole carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: phosphoribosylaminoimidazole carboxylase ADE2

NP_014771.3

EC 4.1.1.21

Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

564476..566191 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183547.3 → NP_014771.3 TPA: phosphoribosylaminoimidazole carboxylase ADE2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014771.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2I6, P21264

UniProtKB/TrEMBL

A6ZNX5, B3LJH0, B5VS18, C7GML1, C8ZI90, G2WN03, N1NVS9

Conserved Domains (1) summary

PLN02948
Location:6 → 569

PLN02948; phosphoribosylaminoimidazole carboxylase