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    WRS1 tryptophan--tRNA ligase WRS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WRS1
    Official Full Name
    tryptophan--tRNA ligase WRS1
    Primary source
    SGD:S000005457
    Locus tag
    YOL097C
    See related
    AllianceGenome:SGD:S000005457; FungiDB:YOL097C; VEuPathDB:YOL097C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRE342
    Summary
    Enables sequence-specific mRNA binding activity and tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WRS1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (136527..137825, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Zhou M, et al. Nucleic Acids Res, 2010 Jun. PMID 20123733, Free PMC Article
    2. Identification and expression of the Saccharomyces cerevisiae cytoplasmic tryptophanyl-tRNA synthetase gene. John TR, et al. Yeast, 1997 Jan. PMID 9046085
    3. Human tryptophanyl-tRNA synthetase can efficiently complement the Saccharoymces cerevisiae homologue, Wrs1P. Johnson JD, et al. FEMS Microbiol Lett, 2002 Oct 29. PMID 12423761
    4. A view into the origin of life: aminoacyl-tRNA synthetases. Ribas de Pouplana L, et al. Cell Mol Life Sci, 2000 Jun. PMID 10950302, Free PMC Article
    5. Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Tyl-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element. Vandenbol M, et al. Yeast, 1995 Sep 15. PMID 7502582

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase WRS1
    NP_014544.1
    • Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      136527..137825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183351.1 → NP_014544.1  TPA: tryptophan--tRNA ligase WRS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X1, E9P8Z9, Q12109
      UniProtKB/TrEMBL
      A6ZNB3, B3LIW6, B5VRF8, C8ZHL8, G2WMD8, N1NX56
      Conserved Domains (1) summary
      cl00015
      Location:25 → 409
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12109.1

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