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    NCS2 Ncs2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NCS2
    Official Full Name
    Ncs2p
    Primary source
    SGD:S000005063
    Locus tag
    YNL119W
    See related
    AllianceGenome:SGD:S000005063; FungiDB:YNL119W; VEuPathDB:YNL119W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TUC2
    Summary
    Predicted to enable sulfurtransferase activity. Involved in several processes, including invasive growth in response to glucose limitation; protein urmylation; and pseudohyphal growth. Located in cytoplasm. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NCS2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (401040..402521)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein MRP35 Neighboring gene protein channel TOM70 Neighboring gene decapping enzyme complex catalytic subunit Neighboring gene malate synthase MLS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA. Alings F, et al. Nucleic Acids Res, 2023 Aug 25. PMID 37462076, Free PMC Article
    2. Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Sinha H, et al. Genetics, 2008 Nov. PMID 18780730, Free PMC Article
    3. QTL analysis of high thermotolerance with superior and downgraded parental yeast strains reveals new minor QTLs and converges on novel causative alleles involved in RNA processing. Yang Y, et al. PLoS Genet, 2013. PMID 23966873, Free PMC Article
    4. Global translational impacts of the loss of the tRNA modification t(6)A in yeast. Thiaville PC, et al. Microb Cell, 2016 Jan 1. PMID 26798630, Free PMC Article
    5. Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications. Bruch A, et al. Genes (Basel), 2018 Oct 23. PMID 30360492, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.
      Title: Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.
    2. Data shsow that loss of Ncs2, Nup60, or Pom152 led to an impaired ability to increase SPB size during metaphase arrest, implicating these proteins in SPB component assembly.
      Title: Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein urmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein urmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA thio-modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ncs2p
    NP_014280.3
    • Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      401040..402521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182957.3 → NP_014280.3  TPA: Ncs2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014280.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B0KZR6, B0KZS5, B0KZU3, B0L006, B3LNX6, D6W163, P53923, Q66R25
      UniProtKB/TrEMBL
      C7GKC6, C8ZGB2, G2WLY7, N1NWJ2
      Conserved Domains (1) summary
      pfam10288
      Location:323 → 446
      CTU2; Cytoplasmic tRNA 2-thiolation protein 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53923.1

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