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    ADE4 amidophosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADE4
    Official Full Name
    amidophosphoribosyltransferase
    Primary source
    SGD:S000004915
    Locus tag
    YMR300C
    See related
    AllianceGenome:SGD:S000004915; FungiDB:YMR300C; VEuPathDB:YMR300C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables amidophosphoribosyltransferase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytoplasm. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADE4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (865559..867091, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene sphingosine N-acyltransferase subunit LIP1 Neighboring gene dynein light intermediate chain Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1 Neighboring gene Yme2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4. Mösch HU, et al. J Biol Chem, 1991 Oct 25. PMID 1939099
    2. Isolation of a human cDNA encoding amidophosphoribosyltransferase and functional complementation of a CHO Ade-A mutant deficient in this activity. Barton JW, et al. Somat Cell Mol Genet, 1991 May. PMID 2047942
    3. [Properties of 5-phosphoryl-1-pyrophosphate amidotransferase from the yeast Saccharomyces cerevisiae wild type and mutant with altered purine biosynthesis regulation]. Smolina VS, et al. Biokhimiia, 1982 Jan. PMID 7039693
    4. Studies on mutants affecting amidophosphoribosyltransferase activity in Saccharomyces cerevisiae. Nieto DJ, et al. Can J Microbiol, 1983 Jun. PMID 6349762
    5. Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase. Mäntsälä P, et al. J Biol Chem, 1984 Jul 10. PMID 6376509

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amidophosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amidophosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amidophosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amidophosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    amidophosphoribosyltransferase
    NP_014029.1
    • Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      865559..867091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182809.1 → NP_014029.1  TPA: amidophosphoribosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014029.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0C7, P04046
      UniProtKB/TrEMBL
      A6ZN16, B3LMI8, B5VQ66, C7GTJ9, G2WL09, N1P632
      Conserved Domains (1) summary
      PRK09246
      Location:1 → 502
      PRK09246; amidophosphoribosyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04046.2

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