TGL3 bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TGL3
Official Full Name: bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase
Primary source: SGD:S000004930
Locus tag: YMR313C
See related: AllianceGenome:SGD:S000004930; FungiDB:YMR313C; VEuPathDB:YMR313C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables lysophosphatidylethanolamine acyltransferase activity and triacylglycerol lipase activity. Involved in cell budding and triglyceride catabolic process. Located in lipid droplet. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TGL3 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (899379..901307, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the topology of Tgl3p is important for its function and strongly dependent on the membrane environment.
Title: Modifications of the C terminus affect functionality and stability of yeast triacylglycerol lipase Tgl3p.
the activity of Tgl3p is restricted to lipid droplets, whereas the endoplasmic reticulum may serve as a parking lot for this enzyme.
Title: Regulation of the yeast triacylglycerol lipase TGl3p by formation of nonpolar lipids.
Results demonstrate that yeast Tgl3p and Tgl5p play a dual role in lipid metabolism contributing to both anabolic and catabolic processes.
Title: Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidylethanolamine acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell budding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in lipid droplet	HDA more info	PubMed
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase

NP_014044.1

EC 3.1.1.3

Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

899379..901307 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182824.1 → NP_014044.1 TPA: bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014044.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0E0, P40308

UniProtKB/TrEMBL

A6ZN30, B3LMK1, B5VQ79, C7GPV0, C8ZFI4, D3YHF6, G2WL22, N1NXU7

Conserved Domains (1) summary

cd07229
Location:130 → 640

Pat_TGL3_like; Triacylglycerol lipase 3