CNA1 calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CNA1
Official Full Name: calcineurin catalytic subunit A
Primary source: SGD:S000004425
Locus tag: YLR433C
See related: AllianceGenome:SGD:S000004425; FungiDB:YLR433C; VEuPathDB:YLR433C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CMP1
Summary: Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in several processes, including cellular response to pheromone; conjugation with cellular fusion; and fungal-type cell wall organization. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CNA1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (1004347..1006008, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data report that heterologous expression of CaZF provides osmotolerance in S. cerevisiae through Hog1p and calcineurin dependent as well as independent pathways.
Title: CaZF, a plant transcription factor functions through and parallel to HOG and calcineurin pathways in Saccharomyces cerevisiae to provide osmotolerance.
ethanol activates the calcineurin/Crz1 pathway and CRZ1 is crucial for cell survival under ethanol-induced stress
Title: Ethanol stress stimulates the Ca2+-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae.
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Title: A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Results demonstrate that calcineurin can positively regulate the transport of cations by the mutant allele VCX1-M1p.
Title: Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p.
target of rapamycin complex 2(TORC2)-SLM signaling negatively regulates calcineurin, and calcineurin negatively regulates TORC2-SLM
Title: Mutual antagonism of target of rapamycin and calcineurin signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
contributes_to calcium-dependent protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pheromone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcineurin catalytic subunit A

NP_013537.1

EC 3.1.3.16

Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

1004347..1006008 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182321.1 → NP_013537.1 TPA: calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013537.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ68, P23287

UniProtKB/TrEMBL

A7A1V3, B3RHU2, C7GSM2, G2WJP4, N1NZX1

Conserved Domains (1) summary

cd07416
Location:70 → 381

MPP_PP2B; PP2B, metallophosphatase domain