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    FAR10 Far10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FAR10
    Official Full Name
    Far10p
    Primary source
    SGD:S000004228
    Locus tag
    YLR238W
    See related
    AllianceGenome:SGD:S000004228; FungiDB:YLR238W; VEuPathDB:YLR238W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in re-entry into mitotic cell cycle after pheromone arrest. Located in endoplasmic reticulum. Orthologous to human TRAF3IP3 (TRAF3 interacting protein 3) and SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FAR10 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (614755..616191)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thiamine transporter THI7 Neighboring gene lipoyl(octanoyl) transferase LIP2 Neighboring gene phosphatidylinositol 3-kinase VPS34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. Lai F, et al. FEMS Yeast Res, 2011 Feb. PMID 20977626
    2. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
    3. Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Innokentev A, et al. Elife, 2020 Dec 15. PMID 33317697, Free PMC Article
    4. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article
    5. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Huang M, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760057

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Far10p
    NP_013339.1
    • Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      614755..616191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182125.1 → NP_013339.1  TPA: Far10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN6, Q06001
      UniProtKB/TrEMBL
      A7A1C1, B3RHC3, B5VNF5, C7GQZ8, C8ZDK1, G2WJ64, N1NZG3
      Conserved Domains (2) summary
      COG1716
      Location:49 → 229
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cl27104
      Location:316 → 432
      Mak16; Mak16 protein C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06001.1

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