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    GPN3 putative signal sequence-binding GTPase GPN3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPN3
    Official Full Name
    putative signal sequence-binding GTPase GPN3
    Primary source
    SGD:S000004233
    Locus tag
    YLR243W
    See related
    AllianceGenome:SGD:S000004233; FungiDB:YLR243W; VEuPathDB:YLR243W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable GTPase activity. Involved in mitotic sister chromatid cohesion and protein import into nucleus. Orthologous to human GPN3 (GPN-loop GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPN3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (624203..625021)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Csc1p Neighboring gene sterol homeostasis protein ARV1 Neighboring gene methionine aminopeptidase MAP1 Neighboring gene cytidine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
    2. Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Minaker SW, et al. Genetics, 2013 Mar. PMID 23267056, Free PMC Article
    3. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
    4. Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN. Alonso B, et al. Cell Cycle, 2013 Feb 1. PMID 23324351, Free PMC Article
    5. A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. Minaker SW, et al. Cell Cycle, 2021 Jul. PMID 34180355, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that the GPN proteins (GPN2 and GPN3) function upstream of Iwr1 in RNA polymerase II and III biogenesis.
      Title: Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
    2. These results suggest that yGPN1 and yGPN2, yGPN3 proteins act at the molecular level in sister chromatid cohesion mechanism as a GPN|GPN complex.
      Title: Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative signal sequence-binding GTPase GPN3
    NP_013344.1
    • Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      624203..625021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182130.1 → NP_013344.1  TPA: putative signal sequence-binding GTPase GPN3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYP1, Q06543
      UniProtKB/TrEMBL
      A7A1C6, B3RHC8, B5VNG0, C7GQZ3, C8ZDK6, G2WJ69, N1NZG7
      Conserved Domains (1) summary
      cd17872
      Location:5 → 251
      GPN3; GPN-loop GTPase 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06543.1

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