DPL1 sphinganine-1-phosphate aldolase DPL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DPL1
Official Full Name: sphinganine-1-phosphate aldolase DPL1
Primary source: SGD:S000002702
Locus tag: YDR294C
See related: AllianceGenome:SGD:S000002702; FungiDB:YDR294C; VEuPathDB:YDR294C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BST1
Summary: Enables sphinganine-1-phosphate aldolase activity. Involved in calcium-mediated signaling; cellular response to starvation; and sphingolipid metabolic process. Located in cortical endoplasmic reticulum and perinuclear endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DPL1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1050459..1052228, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dpl1p exists as an oligomer
Title: Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sphinganine-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphinganine-1-phosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphinganine-1-phosphate aldolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	HDA more info	PubMed

General protein information

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Preferred Names: sphinganine-1-phosphate aldolase DPL1

NP_010580.1

EC 4.1.2.27

Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; localizes to the ER and to the peroxisome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1050459..1052228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180602.1 → NP_010580.1 TPA: sphinganine-1-phosphate aldolase DPL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010580.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSS3, Q05567

UniProtKB/TrEMBL

C7GQU4, C8Z5K6, N1P6T8

Conserved Domains (1) summary

COG0076
Location:106 → 543

GadA; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]