AIR2 TRAMP complex RNA-binding subunit [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: AIR2
Official Full Name: TRAMP complex RNA-binding subunit
Primary source: SGD:S000002334
Locus tag: YDL175C
See related: AllianceGenome:SGD:S000002334; FungiDB:YDL175C; VEuPathDB:YDL175C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA binding activity and protein-macromolecule adaptor activity. Contributes to 3'-5' RNA helicase activity and poly(A) RNA polymerase activity. Involved in nuclear RNA surveillance and tRNA modification. Located in nucleolus. Part of TRAMP complex. Orthologous to human ZCCHC7 (zinc finger CCHC-type containing 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See AIR2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (144484..145518, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purification and characterization of Mtr4 and TRAMP from S. cerevisiae.
Title: Purification and characterization of Mtr4 and TRAMP from S. cerevisiae.
Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger
Title: Cotranscriptional recruitment of RNA exosome cofactors Rrp47p and Mpp6p and two distinct Trf-Air-Mtr4 polyadenylation (TRAMP) complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant messenger ribonucleoprotein particle (mRNP) in yeast.
Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance.
Title: Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance.
Air2p is an RNA-binding subunit of Trf4/5p-Air1/2p-Mtr4p polyadenylation complex (TRAMP).
Title: Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation.
Data show that the unwinding activity of Mtr4p is significantly stimulated by Trf4p/Air2p, but the stimulation of Mtr4p does not depend on ongoing polyadenylation.
Title: RNA unwinding by the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex.
Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.
Title: Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to 3'-5' RNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
contributes_to poly(A) RNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to poly(A) RNA polymerase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in TRAMP-dependent tRNA surveillance pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in TRAMP-dependent tRNA surveillance pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear mRNA surveillance of mRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear mRNA surveillance of mRNA 3'-end processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear polyadenylation-dependent CUT catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent CUT catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent rRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear polyadenylation-dependent snRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear polyadenylation-dependent snoRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear polyadenylation-dependent snoRNA catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in polyadenylation-dependent RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TRAMP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAMP complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TRAMP complex RNA-binding subunit

NP_010106.1

RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

144484..145518 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180235.1 → NP_010106.1 TPA: TRAMP complex RNA-binding subunit [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010106.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRH7, Q12476

UniProtKB/TrEMBL

A6ZXF6, B3LH59, B5VF97, C7GL21, G2WBZ0, N1P7B2

Conserved Domains (1) summary

COG5082
Location:1 → 209

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]