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    proV glycine betaine ABC transporter ATP binding subunit ProV [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947148, updated on 17-Dec-2024

    Summary

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    Official Symbol
    proV
    Official Full Name
    glycine betaine ABC transporter ATP binding subunit ProV
    Primary source
    ECOCYC:EG10771
    Locus tag
    b2677
    See related
    ASAP:ABE-0008814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2671; osrA; proU
    Summary
    ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10771].
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    Genomic context

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    Sequence:
    NC_000913.3 (2804815..2806017)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter membrane subunit ProW Neighboring gene glycine betaine ABC transporter periplasmic binding protein ProX Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selection of mutations that alter the osmotic control of transcription of the Salmonella typhimurium proU operon. Druger-Liotta J, et al. J Bacteriol, 1987 Jun. PMID 3294791, Free PMC Article
    2. A novel, non-invasive promoter probe vector: cloning of the osmoregulated proU promoter of Escherichia coli K12. Park SF, et al. Mol Microbiol, 1989 Aug. PMID 2691837
    3. A sensor for intracellular ionic strength. Biemans-Oldehinkel E, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16815971, Free PMC Article
    4. A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium. Overdier DG, et al. Proc Natl Acad Sci U S A, 1992 Apr 1. PMID 1557423, Free PMC Article
    5. Osmotic signal transduction to proU is independent of DNA supercoiling in Escherichia coli. Ramirez RM, et al. J Bacteriol, 1991 Jan. PMID 1670937, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The proU mRNA is processed by RNase III and this processing is osmoregulated.
      Title: RNase III initiates rapid degradation of proU mRNA upon hypo-osmotic stress in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables osmosensor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine betaine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycine betaine transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of ProVWX complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycine betaine ABC transporter ATP binding subunit ProV
    NP_417163.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2804815..2806017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417163.1 glycine betaine ABC transporter ATP binding subunit ProV [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417163.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1WDS6
      Conserved Domains (1) summary
      PRK10070
      Location:1 → 400
      PRK10070; proline/glycine betaine ABC transporter ATP-binding protein ProV
    Nucleotide Protein
    Heading Accession and Version

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