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    gltS glutamate:sodium symporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948166, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gltS
    Official Full Name
    glutamate:sodium symporter
    Primary source
    ECOCYC:EG10406
    Locus tag
    b3653
    See related
    ASAP:ABE-0011941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3643; gltC
    Summary
    Predicted to be in the ST(3) structural class based on hydropathy profile (Lolkema, 2003), but is was not placed in the very similar IT superfamily in a study using phylogenetic methods (Prakash, 2003). [More information is available at EcoGene: EG10406]. Escherichia coli contains four transporters for the uptake of glutamate (GltIJKL, GltP, GltS, and GadC). [More information is available at EcoCyc: EG10406].
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    Genomic context

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    Sequence:
    NC_000913.3 (3827460..3828665, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA (Gm18) 2'-O-methyltransferase Neighboring gene ATP-dependent DNA helicase RecG Neighboring gene xanthine:H(+) symporter XanP Neighboring gene AsmA family protein YicH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Projection structure by single-particle electron microscopy of secondary transport proteins GltT, CitS, and GltS. Mościcka KB, et al. Biochemistry, 2009 Jul 21. PMID 19518127
    2. Use of homocysteic acid for selecting mutants at the gltS locus of Escherichia coli K12. Essenberg RC. J Gen Microbiol, 1984 Jun. PMID 6384422
    3. Genetic analysis of glutamate transport and glutamate decarboxylase in Escherichia coli. Marcus M, et al. J Bacteriol, 1967 Apr. PMID 5340310, Free PMC Article
    4. Genetic analysis of the glutamate permease in Escherichia coli K-12. Marcus M, et al. J Bacteriol, 1969 Mar. PMID 4887500, Free PMC Article
    5. Sodium-stimulated glutamate transport in osmotically shocked cells and membrane vesicles of Escherichia coli. Miner KM, et al. J Bacteriol, 1974 Mar. PMID 4591944, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper presents the membrane topology analysis of the GltS.
      Title: Membrane topology of the GltS Na+/glutamate permease of Escherichia coli.
    2. Gel filtration indicates a reversible equilibrium of two oligomeric states in detergent solution that we identified as a trimer and hexamer by blue-native gel electrophoresis and cross-linking.
      Title: Structure and function of prokaryotic glutamate transporters from Escherichia coli and Pyrococcus horikoshii.
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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glutamate:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-glutamate transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutamate:sodium symporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3827460..3828665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418110.1 glutamate:sodium symporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418110.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAJ3TXT2
      Conserved Domains (1) summary
      TIGR00210
      Location:2 → 398
      gltS; sodium--glutamate symport carrier (gltS)
    Nucleotide Protein
    Heading Accession and Version

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