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    ribC riboflavin synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945848, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ribC
    Official Full Name
    riboflavin synthase
    Primary source
    ECOCYC:EG11406
    Locus tag
    b1662
    See related
    ASAP:ABE-0005557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1658; ribE
    Summary
    RibC contains two homologous domains. [More information is available at EcoGene: EG11406]. Riboflavin synthase catalyzes the final step in riboflavin biosynthesis, the formation of the carbocyclic ring of riboflavin by dismutation of 6,7-dimethyl-8-ribityllumazine. [More information is available at EcoCyc: EG11406].
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    Genomic context

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    Sequence:
    NC_000913.3 (1742601..1743242, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene purine nucleoside transporter PunC Neighboring gene cyclopropane fatty acyl phospholipid synthase Neighboring gene multidrug efflux pump MdtK Neighboring gene putative adhesin-related protein YdhQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase. Talukdar A, et al. J Org Chem, 2007 Sep 14. PMID 17696548
    2. Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli. Meining W, et al. J Struct Biol, 1998 Jan. PMID 9573620
    3. Riboflavin synthase of Escherichia coli. Effect of single amino acid substitutions on reaction rate and ligand binding properties. Illarionov B, et al. J Biol Chem, 2001 Apr 13. PMID 11278450
    4. Crystal structure of riboflavin synthase. Liao DI, et al. Structure, 2001 May 9. PMID 11377200
    5. The solution structure of the N-terminal domain of riboflavin synthase. Truffault V, et al. J Mol Biol, 2001 Jun 15. PMID 11399071

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables riboflavin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    riboflavin synthase
    NP_416179.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1742601..1743242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416179.1 riboflavin synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416179.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N3C6V1, A0A797M0L5
      Conserved Domains (1) summary
      PRK13020
      Location:1 → 207
      PRK13020; riboflavin synthase subunit alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version

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