Akr1b8 aldo-keto reductase family 1, member B8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1b8provided by MGI
Official Full Name: aldo-keto reductase family 1, member B8provided by MGI
Primary source: MGI:MGI:107673
See related: Ensembl:ENSMUSG00000029762 AllianceGenome:MGI:107673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FR-1; Fgrp; Fgfrp
Summary: Predicted to enable several functions, including NADP binding activity; geranylgeranyl reductase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Predicted to be located in extracellular region; lysosome; and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 34.7), colon adult (RPKM 16.0) and 17 other tissues See more
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Genomic context

Location:: 6 B1; 6 14.91 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (34331081..34345396)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (34354146..34368461)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.
Title: AKR1B8 deficiency drives severe DSS-induced acute colitis through invasion of luminal bacteria and activation of innate immunity.
Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.
Title: Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.
AKR1B8 is a critical protein in the proliferation and injury repair of the colonic epithelium and in the pathogenesis of ulcerative colitis and colitis-associated colorectal cancer, being a new etiopathogenic factor of these diseases.
Title: Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice.
We defined the basal and butylated hydroxyanisole induced expression patterns of Nqo1, AKR1B8, and Ho-1 in the liver and small intestine of C57BL/6 mice.
Title: Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice.
AKR1B8 is a new secretory protein through the lysosomes-mediated non-classical pathway.
Title: Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway.
data suggest that murine AKR1B8 is the ortholog of human AKR1B10.
Title: Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

D6Mit269 (e-PCR), detects polymorphism
- UniSTS:130817

NoName (e-PCR)
- UniSTS:235404

U04204 (e-PCR)
- UniSTS:125643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADP+ binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables indanol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables retinal binding	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldose reductase-related protein 2

Names: AR; aldehyde reductase; fibroblast growth factor-regulated protein; protein FR-1

NP_032038.1

EC 1.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.