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    N4BP3 NEDD4 binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 23138, updated on 10-Dec-2024

    Summary

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    Official Symbol
    N4BP3provided by HGNC
    Official Full Name
    NEDD4 binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:29852
    See related
    Ensembl:ENSG00000145911 MIM:619140; AllianceGenome:HGNC:29852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LZTS4
    Summary
    Acts upstream of with a positive effect on innate immune response. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta (RPKM 5.5), esophagus (RPKM 3.2) and 20 other tissues See more
    Orthologs
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    Genomic context

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    See N4BP3 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178113532..178127034)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178663763..178677271)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177540533..177553082)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23733 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4886 Neighboring gene uncharacterized LOC105377754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16711 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:177541661-177542174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177547789-177548591 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177550999-177551800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177553540-177554200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177554863-177555523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177556537-177557188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177557189-177557840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177559119-177559648 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene Sharpr-MPRA regulatory region 11782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177577953-177578454 Neighboring gene NHP2 ribonucleoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177590971-177591472 Neighboring gene NAD(P)HX epimerase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation. Luo M, et al. Cancer Lett, 2022 Dec 1. PMID 36162713
    2. N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B. Han H, et al. Cancer Sci, 2022 Oct. PMID 35848906, Free PMC Article
    3. The correlation analysis of miRNAs and target genes in metastasis of cervical squamous cell carcinoma. Zhou J, et al. Epigenomics, 2018 Mar. PMID 29343084
    4. N4BP3 Regulates RIG-I-Like Receptor Antiviral Signaling Positively by Targeting Mitochondrial Antiviral Signaling Protein. Wang C, et al. Front Microbiol, 2021. PMID 34880843, Free PMC Article
    5. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
      Title: N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
    2. N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B.
      Title: N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B.
    3. N4BP3 was associated with the survival time of cervical squamous cell carcinoma patients. mir-451 and mir-486 were related to tumor differentiation stage.
      Title: The correlation analysis of miRNAs and target genes in metastasis of cervical squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0341

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015111.2 → NP_055926.1  NEDD4-binding protein 3

      See identical proteins and their annotated locations for NP_055926.1

      Status: VALIDATED

      Source sequence(s)
      AC136632
      Consensus CDS
      CCDS34307.1
      UniProtKB/Swiss-Prot
      B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
      Related
      ENSP00000274605.4, ENST00000274605.6
      Conserved Domains (1) summary
      pfam06818
      Location:368 → 526
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      178113532..178127034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534473.2 → XP_011532775.1  NEDD4-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011532775.1

      UniProtKB/Swiss-Prot
      B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
      Conserved Domains (1) summary
      pfam06818
      Location:368 → 526
      Fez1

    2. XM_011534474.2 → XP_011532776.1  NEDD4-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011532776.1

      UniProtKB/Swiss-Prot
      B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
      Conserved Domains (1) summary
      pfam06818
      Location:368 → 526
      Fez1

    3. XM_047416998.1 → XP_047272954.1  NEDD4-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3

    4. XM_047416997.1 → XP_047272953.1  NEDD4-binding protein 3 isoform X1

      UniProtKB/Swiss-Prot
      B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3

    RNA

    1. XR_941094.2 RNA Sequence

    2. XR_941093.2 RNA Sequence

    3. XR_007058594.1 RNA Sequence

    4. XR_007058596.1 RNA Sequence

    5. XR_007058597.1 RNA Sequence

    6. XR_007058595.1 RNA Sequence

    7. XR_007058598.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      178663763..178677271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352158.1 → XP_054208133.1  NEDD4-binding protein 3 isoform X1

    2. XM_054352159.1 → XP_054208134.1  NEDD4-binding protein 3 isoform X1

    3. XM_054352160.1 → XP_054208135.1  NEDD4-binding protein 3 isoform X1

    RNA

    1. XR_008487106.1 RNA Sequence

    2. XR_008487103.1 RNA Sequence

    3. XR_008487104.1 RNA Sequence

    4. XR_008487107.1 RNA Sequence

    5. XR_008487108.1 RNA Sequence

    6. XR_008487105.1 RNA Sequence

    7. XR_008487109.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15049.3 GenPept UniProtKB/Swiss-Prot:O15049

    Gene LinkOut

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