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    Suz12 SUZ12 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 52615, updated on 9-Dec-2024

    Summary

    Official Symbol
    Suz12provided by MGI
    Official Full Name
    SUZ12 polycomb repressive complex 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1261758
    See related
    Ensembl:ENSMUSG00000017548 AllianceGenome:MGI:1261758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0160; D11Ertd530e; 2610028O16Rik
    Summary
    This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
    Expression
    Broad expression in liver E14 (RPKM 18.5), CNS E11.5 (RPKM 16.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Suz12 in Genome Data Viewer
    Location:
    11 B5; 11 47.36 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79883932..79924949)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79993106..80034123)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene UTP6 small subunit processome component Neighboring gene STARR-positive B cell enhancer ABC_E907 Neighboring gene STARR-seq mESC enhancer starr_30132 Neighboring gene predicted gene, 30875 Neighboring gene STARR-positive B cell enhancer ABC_E9368 Neighboring gene cytokine receptor-like factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79881110-79881263 Neighboring gene STARR-seq mESC enhancer starr_30136 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_30137 Neighboring gene STARR-seq mESC enhancer starr_30138

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0160

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in facultative heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within random inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ESC/E(Z) complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polycomb protein Suz12
    Names
    suppressor of zeste 12 homolog
    suppressor of zeste 12 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163018.1NP_001156490.1  polycomb protein Suz12 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AK076010, BC064461
      Consensus CDS
      CCDS48860.1
      UniProtKB/TrEMBL
      E9PW15
      Related
      ENSMUSP00000126932.2, ENSMUST00000163272.2
      Conserved Domains (1) summary
      pfam09733
      Location:525659
      VEFS-Box; VEFS-Box of polycomb protein
    2. NM_199196.2NP_954666.1  polycomb protein Suz12 isoform 1

      See identical proteins and their annotated locations for NP_954666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK076010, BC064461
      Consensus CDS
      CCDS25125.1
      UniProtKB/Swiss-Prot
      B1AQE5, Q80U70, Q80Y10, Q99L07
      Related
      ENSMUSP00000017692.9, ENSMUST00000017692.15
      Conserved Domains (1) summary
      pfam09733
      Location:548682
      VEFS-Box; VEFS-Box of polycomb protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79883932..79924949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)