Defa-rs2 defensin, alpha, related sequence 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Defa-rs2provided by MGI
Official Full Name: defensin, alpha, related sequence 2provided by MGI
Primary source: MGI:MGI:99592
See related: AllianceGenome:MGI:99592
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRS4C; CRS4C-1; CRS4C1d; CRS4C1e; CRS4C1f; CRS4C1g; CRS4C1h; CRS4C1i; CRS4C1j; Defcr-rs2; Defcr-rs3
Summary: Predicted to enable pore-forming activity and protein homodimerization activity. Acts upstream of or within defense response to bacterium and disruption of plasma membrane integrity in another organism. Located in secretory granule. Is expressed in embryo; hindgut diverticulum; node; and notochord. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA3 (defensin alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

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See Defa-rs2 in Genome Data Viewer

Location:: chromosome: 8

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in ileitis-prone mice, Paneth cell levels of CRS4C mRNAs and peptides are induced more than a 1000-fold relative to non-prone strains as early as 4 weeks of age.
Title: Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pore-forming activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in disruption of plasma membrane integrity in another organism	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within disruption of plasma membrane integrity in another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-defensin-related sequence 2

Names: cryptdin related sequence peptide; cryptdin-related protein 4C-1; defensin related cryptdin, related sequence 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007847.1 → NP_031873.1 alpha-defensin-related sequence 2 precursor

See identical proteins and their annotated locations for NP_031873.1

Status: PROVISIONAL

Source sequence(s)

M33227

UniProtKB/Swiss-Prot

P17534, Q64111

UniProtKB/TrEMBL

Q70LV8

Conserved Domains (1) summary

pfam00879
Location:15 → 51

Defensin_propep; Defensin propeptide