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    Trp53rkb transformation related protein 53 regulating kinase B [ Mus musculus (house mouse) ]

    Gene ID: 76367, updated on 28-Jan-2025

    Summary

    Official Symbol
    Trp53rkbprovided by MGI
    Official Full Name
    transformation related protein 53 regulating kinase Bprovided by MGI
    Primary source
    MGI:MGI:1914050
    See related
    Ensembl:ENSMUSG00000042854 AllianceGenome:MGI:1914050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRPK; Nori-2; Tp53rk; Tp53rkb; Trp53rk; Trp53tk; mNori-2p; 2810408M09Rik; 4933401B08Rik; 5630401H01Rik
    Summary
    Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; forelimb bud; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 2.8) and 28 other tissues See more
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    Genomic context

    See Trp53rkb in Genome Data Viewer
    Location:
    2 H3; 2 87.22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166634379..166641412)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166792459..166799492)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1259 Neighboring gene predicted gene, 46777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:166571427-166571628 Neighboring gene predicted gene, 31117 Neighboring gene STARR-positive B cell enhancer ABC_E6021 Neighboring gene ARF guanine nucleotide exchange factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10161 Neighboring gene STARR-positive B cell enhancer ABC_E2654 Neighboring gene STARR-seq mESC enhancer starr_06416 Neighboring gene STARR-positive B cell enhancer ABC_E2655 Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    General gene information

    Clone Names

    • MGC2882

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables hydrolase activity  
    enables p53 binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in protein phosphorylation  
    involved_in tRNA processing  
    involved_in tRNA threonylcarbamoyladenosine metabolic process  
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex  
    part_of EKC/KEOPS complex  
    part_of EKC/KEOPS complex  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    EKC/KEOPS complex subunit Tp53rkb
    Names
    EKC/KEOPS complex subunit Tp53rk
    TP53-regulating kinase
    Trp53 regulating kinase
    atypical serine/threonine protein kinase Tp53rk
    p53-related protein kinase
    NP_076304.2
    XP_006500434.1
    XP_030108048.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023815.5NP_076304.2  EKC/KEOPS complex subunit Tp53rkb

      See identical proteins and their annotated locations for NP_076304.2

      Status: VALIDATED

      Source sequence(s)
      AL591703
      Consensus CDS
      CCDS17090.1
      UniProtKB/Swiss-Prot
      Q91W37, Q99PW4, Q9CZ32
      UniProtKB/TrEMBL
      Q543M9
      Related
      ENSMUSP00000115353.2, ENSMUST00000151826.2
      Conserved Domains (1) summary
      COG3642
      Location:27244
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      166634379..166641412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500371.4XP_006500434.1  EKC/KEOPS complex subunit Tp53rkb isoform X1

      UniProtKB/Swiss-Prot
      Q91W37, Q99PW4, Q9CZ32
      Conserved Domains (1) summary
      COG3642
      Location:51268
      Bud32; tRNA A-37 threonylcarbamoyl transferase component Bud32 [Translation, ribosomal structure and biogenesis]
    2. XM_030252188.2XP_030108048.1  EKC/KEOPS complex subunit Tp53rkb isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1141
      PKc_like; Protein Kinases, catalytic domain
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