Lrfn4 leucine rich repeat and fibronectin type III domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrfn4provided by MGI
Official Full Name: leucine rich repeat and fibronectin type III domain containing 4provided by MGI
Primary source: MGI:MGI:2385612
See related: Ensembl:ENSMUSG00000045045 AllianceGenome:MGI:2385612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Salm3
Summary: Involved in regulation of postsynaptic density assembly; regulation of presynapse assembly; and synaptic membrane adhesion. Located in cell surface. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; liver; primary head vein; reproductive system; and sensory organ. Orthologous to human LRFN4 (leucine rich repeat and fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 41.2), colon adult (RPKM 28.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.07 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4661817..4665720, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4611784..4615667, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPsigma.
Title: Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ.
SALM4 cis-interacts with SALM3, inhibits trans-synaptic SALM3 interaction with presynaptic LAR family receptor tyrosine phosphatases and suppresses SALM3-dependent presynaptic differentiation.
Title: SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.
Data show that the C-terminal PDZ binding domains of synaptic adhesion-like molecules (SALMs)1-3 are required for neurite outgrowth, and that the N-termini of SALMs 2 and 4 are alsoinvolved in neurite outgrowth.
Title: Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.
Expression of SALM family proteins SALM3 and SALM5 in nonneural and neural cells induces both excitatory and inhibitory presynaptic differentiation in contacting axons.
Title: Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lrfn4 (e-PCR), detects polymorphism
- UniSTS:525548

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of postsynaptic density assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat and fibronectin type-III domain-containing protein 4

Names: synaptic adhesion-like molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426059.1 → NP_001412988.1 leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor

Status: VALIDATED

Source sequence(s)

AC128739

UniProtKB/Swiss-Prot

Q3TQG8, Q460G5, Q80XU8, Q8K3C4

Related

ENSMUSP00000050039.3, ENSMUST00000053597.3
NM_153388.5 → NP_700437.2 leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor

See identical proteins and their annotated locations for NP_700437.2

Status: VALIDATED

Source sequence(s)

AC128739

Consensus CDS

CCDS29431.1

UniProtKB/Swiss-Prot

Q3TQG8, Q460G5, Q80XU8, Q8K3C4

Related

ENSMUSP00000109453.3, ENSMUST00000113822.3

Conserved Domains (5) summary

smart00082
Location:234 → 278

LRRCT; Leucine rich repeat C-terminal domain

COG4886
Location:39 → 205

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:50 → 73

LRR_RI; leucine-rich repeat [structural motif]

pfam00041
Location:409 → 478

fn3; Fibronectin type III domain

cl11960
Location:295 → 368

Ig; Immunoglobulin domain