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    UBE2N ubiquitin conjugating enzyme E2 N [ Homo sapiens (human) ]

    Gene ID: 7334, updated on 10-Dec-2024

    Summary

    Official Symbol
    UBE2Nprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Nprovided by HGNC
    Primary source
    HGNC:HGNC:12492
    See related
    Ensembl:ENSG00000177889 MIM:603679; AllianceGenome:HGNC:12492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC13; UbcH13; UBCHBEN; HEL-S-71; UbcH-ben; UBCHBEN; UBC13
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 12.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See UBE2N in Genome Data Viewer
    Location:
    12q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (93405684..93441947, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (93386662..93422932, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93799460..93835723, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC643339 Neighboring gene small nucleolar RNA SNORD74 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6767 Neighboring gene HNF4 motif-containing MPRA enhancer 125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93729207-93729708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93729709-93730208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93731209-93731709 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:93741082-93741250 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4704 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93764071-93765034 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:93771297-93772236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6768 Neighboring gene nudix hydrolase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4709 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93835621-93836258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6770 Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene uncharacterized LOC124902985 Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (590 hits/1272 screens)

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Heterodimeric E2 UBC13-UEV1A and the arginine 63-linked ubiquitin chains play a role in TRIM5alpha-mediated signaling, which leads to capsid-specific restriction PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC8489, MGC131857

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    acts_upstream_of DNA double-strand break processing PubMed 
    involved_in T cell receptor signaling pathway PubMed 
    involved_in antiviral innate immune response PubMed 
    acts_upstream_of double-strand break repair via homologous recombination PubMed 
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in positive regulation of DNA repair PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of double-strand break repair PubMed 
    involved_in positive regulation of intracellular signal transduction PubMed 
    involved_in positive regulation of protein K63-linked ubiquitination PubMed 
    involved_in postreplication repair  
    acts_upstream_of postreplication repair PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in protein K63-linked ubiquitination  
    involved_in protein K63-linked ubiquitination PubMed 
    involved_in protein K63-linked ubiquitination PubMed 
    involved_in protein monoubiquitination PubMed 
    involved_in protein polyubiquitination PubMed 
    involved_in protein ubiquitination PubMed 
    involved_in regulation of DNA repair PubMed 
    involved_in regulation protein catabolic process at postsynapse  
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex PubMed 
    part_of UBC13-MMS2 complex PubMed 
    is_active_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in extracellular exosome PubMed 
    located_in glutamatergic synapse  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in postsynapse  
    part_of protein-containing complex PubMed 
    part_of ubiquitin conjugating enzyme complex PubMed 
    part_of ubiquitin ligase complex PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 N
    Names
    E2 ubiquitin-conjugating enzyme N
    bendless-like ubiquitin conjugating enzyme
    epididymis secretory protein Li 71
    ubiquitin carrier protein N
    ubiquitin conjugating enzyme E2N
    ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
    ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
    ubiquitin-protein ligase N
    yeast UBC13 homolog
    NP_003339.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003348.4 → NP_003339.1  ubiquitin-conjugating enzyme E2 N

      See identical proteins and their annotated locations for NP_003339.1

      Status: REVIEWED

      Source sequence(s)
      AC025260, AK098233, BC000396, CB243041
      Consensus CDS
      CCDS31875.1
      UniProtKB/Swiss-Prot
      P61088, Q16781, Q53Y81
      UniProtKB/TrEMBL
      V9HW41
      Related
      ENSP00000316176.2, ENST00000318066.7
      Conserved Domains (1) summary
      cl00154
      Location:4 → 151
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      93405684..93441947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      93386662..93422932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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