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    Ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 67418, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ppil4provided by MGI
    Official Full Name
    peptidylprolyl isomerase (cyclophilin)-like 4provided by MGI
    Primary source
    MGI:MGI:1914668
    See related
    Ensembl:ENSMUSG00000015757 AllianceGenome:MGI:1914668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PPIase; 3732410E19Rik; 3830425H19Rik
    Summary
    Predicted to enable RNA binding activity; RNA polymerase II CTD heptapeptide repeat P3 isomerase activity; and RNA polymerase II CTD heptapeptide repeat P6 isomerase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.7), CNS E14 (RPKM 9.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppil4 in Genome Data Viewer
    Location:
    10 A1; 10 2.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7668653..7698329)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7792889..7822565)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6817 Neighboring gene katanin p60 (ATPase-containing) subunit A1 Neighboring gene STARR-positive B cell enhancer ABC_E9338 Neighboring gene glycoprotein integral membrane 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:7529819-7530120 Neighboring gene STARR-positive B cell enhancer ABC_E5118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:7559346-7559529 Neighboring gene zinc finger CCCH type containing 12D Neighboring gene microRNA 5104 Neighboring gene predicted gene, 24726

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain. Zeng L, et al. Cytogenet Cell Genet, 2001. PMID 11978968
    2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase-like 4
    Names
    cyclophilin-like protein PPIL4
    rotamase PPIL4
    NP_080417.2
    XP_006512895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429484.1 → NP_001416413.1  peptidyl-prolyl cis-trans isomerase-like 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159137
      UniProtKB/TrEMBL
      Q9CSN5

    2. NM_026141.4 → NP_080417.2  peptidyl-prolyl cis-trans isomerase-like 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159137
      Consensus CDS
      CCDS23690.1
      UniProtKB/Swiss-Prot
      Q3TJX1, Q68FC7, Q9CT22, Q9CXG3
      UniProtKB/TrEMBL
      Q9D3J1
      Related
      ENSMUSP00000015901.5, ENSMUST00000015901.11
      Conserved Domains (3) summary
      COG0724
      Location:193 → 320
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01921
      Location:4 → 161
      cyclophilin_RRM; cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain ...
      cd12235
      Location:237 → 319
      RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

    RNA

    1. NR_190739.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159137

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      7668653..7698329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512832.5 → XP_006512895.1  peptidyl-prolyl cis-trans isomerase-like 4 isoform X1

      Conserved Domains (2) summary
      cd01921
      Location:4 → 161
      cyclophilin_RRM; cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain including the ...
      cd12235
      Location:237 → 319
      RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

    RNA

    1. XR_004936262.1 RNA Sequence

    2. XR_004936263.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXG3.2 GenPept UniProtKB/Swiss-Prot:Q9CXG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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