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    Cenps centromere protein S [ Mus musculus (house mouse) ]

    Gene ID: 69928, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cenpsprovided by MGI
    Official Full Name
    centromere protein Sprovided by MGI
    Primary source
    MGI:MGI:1917178
    See related
    Ensembl:ENSMUSG00000073705 AllianceGenome:MGI:1917178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apitd1; CENP-S; 2610040C18Rik; 2810407L01Rik
    Summary
    Predicted to enable DNA binding activity and chromatin binding activity. Predicted to contribute to double-stranded DNA binding activity. Predicted to be involved in DNA repair; replication fork processing; and resolution of meiotic recombination intermediates. Predicted to be located in chromatin. Predicted to be part of FANCM-MHF complex; Fanconi anaemia nuclear complex; and inner kinetochore. Is expressed in brain; sensory organ; skeleton; and testis. Orthologous to human CENPS-CORT (CENPS-CORT readthrough) and CENPS (centromere protein S). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.2), liver E14 (RPKM 8.1) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Cenps in Genome Data Viewer
    Location:
    4 E2; 4 78.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149212806..149222057, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149128349..149137600, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9626 Neighboring gene DNA fragmentation factor, alpha subunit Neighboring gene STARR-seq mESC enhancer starr_12102 Neighboring gene cortistatin Neighboring gene STARR-positive B cell enhancer ABC_E4730 Neighboring gene STARR-positive B cell enhancer ABC_E11279 Neighboring gene STARR-positive B cell enhancer ABC_E4731 Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12104 Neighboring gene phosphogluconate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E3554

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC58422

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA binding  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin binding  
    contributes_to double-stranded DNA binding  
    contributes_to double-stranded DNA binding  
    enables protein heterodimerization activity  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in cell division  
    involved_in chromosome segregation PubMed 
    involved_in interstrand cross-link repair  
    involved_in replication fork processing  
    involved_in replication fork processing  
    involved_in resolution of meiotic recombination intermediates  
    involved_in resolution of meiotic recombination intermediates  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex  
    part_of FANCM-MHF complex  
    part_of FANCM-MHF complex  
    part_of Fanconi anaemia nuclear complex  
    part_of Fanconi anaemia nuclear complex  
    part_of Fanconi anaemia nuclear complex  
    located_in chromatin  
    located_in chromatin  
    part_of inner kinetochore  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    centromere protein S
    Names
    FANCM-interacting histone fold protein 1
    apoptosis-inducing TAF9-like domain-containing protein 1 homolog
    apoptosis-inducing, TAF9-like domain 1
    ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027263.2NP_081539.1  centromere protein S

      See identical proteins and their annotated locations for NP_081539.1

      Status: VALIDATED

      Source sequence(s)
      AK011725, DV656255
      Consensus CDS
      CCDS18954.1
      UniProtKB/Swiss-Prot
      A2AH77, Q80ZS2, Q8BH28, Q9D084
      UniProtKB/TrEMBL
      B2KFX4
      Related
      ENSMUSP00000030813.4, ENSMUST00000030813.10
      Conserved Domains (1) summary
      pfam15630
      Location:1691
      CENP-S; Kinetochore component CENP-S

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149212806..149222057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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