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    Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 [ Mus musculus (house mouse) ]

    Gene ID: 68350, updated on 13-Jan-2025

    Summary

    Official Symbol
    Mul1provided by MGI
    Official Full Name
    mitochondrial ubiquitin ligase activator of NFKB 1provided by MGI
    Primary source
    MGI:MGI:1915600
    See related
    Ensembl:ENSMUSG00000041241 AllianceGenome:MGI:1915600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gide; 0610009K11Rik
    Summary
    Predicted to enable several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of dendrite extension; positive regulation of type 2 mitophagy; and regulation of protein stability. Located in mitochondrion. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.6), colon adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mul1 in Genome Data Viewer
    Location:
    4 D3; 4 70.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138160239..138169576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138434660..138442265)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein, MNCb-2457 Neighboring gene family with sequence similarity 43, member B Neighboring gene ribosomal protein L38, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8003 Neighboring gene STARR-seq mESC enhancer starr_11803 Neighboring gene STARR-seq mESC enhancer starr_11805 Neighboring gene STARR-seq mESC enhancer starr_11806 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1 Neighboring gene predicted gene, 32549

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO transferase activity  
    enables SUMO transferase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables p53 binding  
    enables p53 binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to exogenous dsRNA  
    involved_in cellular response to exogenous dsRNA  
    involved_in mitochondrial fission  
    involved_in mitochondrial fission  
    involved_in mitochondrion localization  
    involved_in mitochondrion localization  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production  
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production  
    involved_in negative regulation of defense response to virus by host  
    involved_in negative regulation of defense response to virus by host  
    involved_in negative regulation of innate immune response  
    involved_in negative regulation of innate immune response  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of dendrite extension PubMed 
    involved_in positive regulation of dendrite extension PubMed 
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of protein sumoylation  
    involved_in positive regulation of protein sumoylation  
    involved_in positive regulation of type 2 mitophagy PubMed 
    involved_in protein destabilization  
    involved_in protein destabilization  
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein sumoylation  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in regulation of mitochondrial membrane potential PubMed 
    involved_in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
    involved_in regulation of mitochondrion organization  
    involved_in regulation of protein stability PubMed 
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in peroxisome  
    located_in peroxisome  

    General protein information

    Preferred Names
    mitochondrial ubiquitin ligase activator of NFKB 1
    Names
    E3 ubiquitin ligase
    E3 ubiquitin-protein ligase MUL1
    RING-type E3 ubiquitin transferase NFKB 1
    growth inhibition and death E3 ligase
    protein Hades
    NP_080965.2
    XP_006539197.1
    XP_036020280.1
    XP_036020281.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026689.3NP_080965.2  mitochondrial ubiquitin ligase activator of NFKB 1

      See identical proteins and their annotated locations for NP_080965.2

      Status: VALIDATED

      Source sequence(s)
      AK076419, AK083295, BB856128, BY062056
      Consensus CDS
      CCDS18828.1
      UniProtKB/Swiss-Prot
      A2AM82, A2AM84, B5M498, Q3TDK4, Q8BHF2, Q8VCM5, Q9DCV9
      Related
      ENSMUSP00000039604.5, ENSMUST00000044058.11
      Conserved Domains (2) summary
      pfam12483
      Location:97251
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:302346
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138160239..138169576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539134.5XP_006539197.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X2

      See identical proteins and their annotated locations for XP_006539197.1

      UniProtKB/Swiss-Prot
      Q8VCM5
      Related
      ENSMUSP00000101439.2, ENSMUST00000105813.8
      Conserved Domains (2) summary
      cd16648
      Location:296335
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:92248
      GIDE; E3 Ubiquitin ligase
    2. XM_036164388.1XP_036020281.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X3

      Conserved Domains (2) summary
      cd16648
      Location:201240
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:3153
      GIDE; E3 Ubiquitin ligase
    3. XM_036164387.1XP_036020280.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1

      Conserved Domains (2) summary
      cd16648
      Location:327366
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:123279
      GIDE; E3 Ubiquitin ligase
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