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    ztf-11 Zinc finger protein ztf-11 [ Caenorhabditis elegans ]

    Gene ID: 172845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ztf-11
    Official Full Name
    Zinc finger protein ztf-11
    Primary source
    WormBase:WBGene00009939
    Locus tag
    CELE_F52F12.6
    See related
    AllianceGenome:WB:WBGene00009939
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neuron differentiation; and positive regulation of cell differentiation. Located in nucleus. Is expressed in g1 and head neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to several human genes including MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ztf-11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9904303..9910545, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Mitogen-activated protein kinase kinase kinase mom-4 Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing the alternative. Sivaramakrishnan P, et al. Elife, 2019 Aug 6. PMID 31386622, Free PMC Article
    2. A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. Lee J, et al. Elife, 2019 Aug 6. PMID 31386623, Free PMC Article
    3. Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx. Raharjo WH, et al. Genetics, 2011 Nov. PMID 21868609, Free PMC Article
    4. The transcription factor HLH-26 controls probiotic-mediated protection against intestinal infection through up-regulation of the Wnt/BAR-1 pathway. Sang Y, et al. PLoS Biol, 2022 Mar. PMID 35263319, Free PMC Article
    5. A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis. Xu W, et al. Nat Commun, 2024 Mar 30. PMID 38555276, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein ztf-11
    NP_001251245.1
    • Confirmed by transcript evidence
    NP_001251246.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9904303..9910545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264316.3 → NP_001251245.1  Zinc finger protein ztf-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L2J7, O02274
      UniProtKB/TrEMBL
      Q94138
      Conserved Domains (1) summary
      pfam01530
      Location:265 → 291
      zf-C2HC; Zinc finger, C2HC type

    2. NM_001264317.3 → NP_001251246.1  Zinc finger protein ztf-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q94138
      Conserved Domains (1) summary
      pfam01530
      Location:168 → 193
      zf-C2HC; Zinc finger, C2HC type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02274.3

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