U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    unc-71 Disintegrin and metalloproteinase domain-containing protein unc-71 [ Caenorhabditis elegans ]

    Gene ID: 176706, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    unc-71
    Official Full Name
    Disintegrin and metalloproteinase domain-containing protein unc-71
    Primary source
    WormBase:WBGene00006804
    Locus tag
    CELE_Y37D8A.13
    See related
    AllianceGenome:WB:WBGene00006804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Is expressed in several structures, including buccal cavity; excretory system; hypodermis; nerve ring; and neuronal sheath cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to several human genes including ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See unc-71 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (12881043..12891738, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Signal peptidase complex subunit 2 Neighboring gene Chromo domain-containing protein Neighboring gene ENhancer of Uncoordination Neighboring gene Uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 5A, mitochondrial Neighboring gene KHEYLRF-amide 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans. Podbilewicz B. Mol Biol Cell, 1996 Dec. PMID 8970152, Free PMC Article
    2. UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans. Huang X, et al. Development, 2003 Jul. PMID 12783787
    3. MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans. Masuda H, et al. FEBS Lett, 2012 Mar 23. PMID 22293500
    4. Genetic mosaics. Yochem J, et al. WormBook, 2005 Dec 27. PMID 18023118, Free PMC Article
    5. Distinct cell guidance pathways controlled by the Rac and Rho GEF domains of UNC-73/TRIO in Caenorhabditis elegans. Marcus-Gueret N, et al. Genetics, 2012 Jan. PMID 21996675, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
      Title: MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
    2. results indicate unc-71 acts in a cell non-autonomous manner for motor axon guidance and sex myoblast migration; probably functions with integrins and UNC-6/netrin to provide axon guidance cues at specific choice points for motoneurons
      Title: UNC-71, a disintegrin and metalloprotease (ADAM) protein, regulates motor axon guidance and sex myoblast migration in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Disintegrin and metalloproteinase domain-containing protein unc-71
    NP_499680.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12881043..12891738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067279.8 → NP_499680.1  Disintegrin and metalloproteinase domain-containing protein unc-71 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFD5
      Conserved Domains (5) summary
      smart00050
      Location:446 → 521
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:524 → 657
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:227 → 429
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam07974
      Location:666 → 698
      EGF_2; EGF-like domain
      pfam01562
      Location:46 → 179
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFD5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.