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    fut-1 Alpha-(1,3)-fucosyltransferase fut-1 [ Caenorhabditis elegans ]

    Gene ID: 174400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fut-1
    Official Full Name
    Alpha-(1,3)-fucosyltransferase fut-1
    Primary source
    WormBase:WBGene00001505
    Locus tag
    CELE_K08F8.3
    See related
    AllianceGenome:WB:WBGene00001505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and glycoprotein 3-alpha-L-fucosyltransferase activity. Involved in carbohydrate biosynthetic process and fucosylation. Predicted to be located in Golgi membrane. Is expressed in chemosensory neurons; pharyngeal-intestinal valve; rectal valve cell; and retrovesicular ganglion. Orthologous to several human genes including FUT3 (fucosyltransferase 3 (Lewis blood group)); FUT5 (fucosyltransferase 5); and FUT6 (fucosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fut-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (8756295..8758631, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene Phenylalanine-4-hydroxylase Neighboring gene Nematode Specific Peptide family Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans. DeBose-Boyd RA, et al. Glycobiology, 1998 Sep. PMID 9675224
    2. Protein O-Fucosyltransferase 1 Undergoes Interdomain Flexibility in Solution. Lira-Navarrete E, et al. Molecules, 2021 Apr 7. PMID 33916911, Free PMC Article
    3. Definition of immunogenic carbohydrate epitopes. Paschinger K, et al. Acta Biochim Pol, 2005. PMID 16175237
    4. Distantly related plant and nematode core α1,3-fucosyltransferases display similar trends in structure-function relationships. Both P, et al. Glycobiology, 2011 Nov. PMID 21515584, Free PMC Article
    5. Comparisons of Caenorhabditis Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N-Glycan Structures. Yan S, et al. J Proteome Res, 2015 Dec 4. PMID 26538210, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-(1->3)-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycoprotein 3-alpha-L-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycoprotein 3-alpha-L-fucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fucosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-(1,3)-fucosyltransferase fut-1
    NP_001369885.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8756295..8758631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383908.2 → NP_001369885.1  Alpha-(1,3)-fucosyltransferase fut-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDR5
      Conserved Domains (2) summary
      pfam00852
      Location:234 → 405
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:117 → 210
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDR5.1

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