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    hrpk-1 Heterogeneous nuclear ribonucleoprotein K homolog [ Caenorhabditis elegans ]

    Gene ID: 172330, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrpk-1
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein K homolog
    Primary source
    WormBase:WBGene00017816
    Locus tag
    CELE_F26B1.2
    See related
    AllianceGenome:WB:WBGene00017816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in DNA damage response and embryo development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including germ line; hypodermal cell; intestinal cell; muscle cell; and oocyte. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hrpk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (6317701..6320364)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-14 Neighboring gene Importin subunit alpha-2 Neighboring gene Forkhead box protein F Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development. Li L, et al. PLoS Genet, 2019 Oct. PMID 31584932, Free PMC Article
    2. Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans. Holway AH, et al. Genetics, 2005 Mar. PMID 15654100, Free PMC Article
    3. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    4. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Heterogeneous nuclear ribonucleoprotein K homolog
    NP_001379657.1
    • Confirmed by transcript evidence
    NP_001379658.1
    • Confirmed by transcript evidence
    NP_001379659.1
    • Confirmed by transcript evidence
    NP_001379660.1
    • Confirmed by transcript evidence
    NP_740869.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6317701..6320364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170880.6 → NP_740869.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91277, Q8I7G7, Q8I7G8, Q8I7G9, Q8T3B5
      Conserved Domains (3) summary
      cd22432
      Location:49 → 112
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22433
      Location:124 → 193
      KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22434
      Location:316 → 388
      KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

    2. NM_001392429.1 → NP_001379660.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd22432
      Location:49 → 93
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins

    3. NM_001392432.1 → NP_001379657.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00098
      Location:32 → 61
      KH-I; K homology (KH) RNA-binding domain, type I

    4. NM_001392433.1 → NP_001379659.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00098
      Location:32 → 61
      KH-I; K homology (KH) RNA-binding domain, type I

    5. NM_001392431.1 → NP_001379658.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd22432
      Location:32 → 95
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22433
      Location:107 → 176
      KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22434
      Location:299 → 371
      KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91277.1

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