ccpp-1 Cytosolic carboxypeptidase 1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ccpp-1
Official Full Name: Cytosolic carboxypeptidase 1
Primary source: WormBase:WBGene00018995
Locus tag: CELE_F56H1.5
See related: AllianceGenome:WB:WBGene00018995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Involved in egg-laying behavior. Predicted to be located in cilium; dendrite; and perikaryon. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in gubernacular muscle and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to several human genes including AGBL1 (AGBL carboxypeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ccpp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 18

Sequence:: Chromosome: I; NC_003279.8 (5754312..5760799, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCPP-1 acts as a tubulin deglutamylase that regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia of a multicellular, living animal.
Title: The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.
Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.
Title: Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS1-19 (e-PCR)
- UniSTS:241680

F56H1.5 (e-PCR)
- UniSTS:311883

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Cytosolic carboxypeptidase 1

NP_491674.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5754312..5760799 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059273.7 → NP_491674.2 Cytosolic carboxypeptidase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491674.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O76373

Conserved Domains (1) summary

cd06235
Location:738 → 1011

M14_Nna1_like_2; Peptidase M14-like domain of human Nna1/AGTPBP-1, AGBL2 -5, and related proteins