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    fem-2 Protein phosphatase fem-2 [ Caenorhabditis elegans ]

    Gene ID: 175217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fem-2
    Official Full Name
    Protein phosphatase fem-2
    Primary source
    WormBase:WBGene00001412
    Locus tag
    CELE_T19C3.8
    See related
    AllianceGenome:WB:WBGene00001412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including masculinization of hermaphroditic germ-line; nematode male tail tip morphogenesis; and peptidyl-threonine dephosphorylation. Part of protein-containing complex. Orthologous to several human genes including PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fem-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (632019..634626, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Ribosome maturation protein SBDS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans sex-determining gene fem-2 encodes a putative protein phosphatase. Pilgrim D, et al. Mol Biol Cell, 1995 Sep. PMID 8534913, Free PMC Article
    2. Parental DNA strands segregate randomly during embryonic development of Caenorhabditis elegans. Ito K, et al. Cell, 1987 May 8. PMID 3568128
    3. Molecular evolution of a sex determination protein. FEM-2 (pp2c) in Caenorhabditis. Hansen D, et al. Genetics, 1998 Jul. PMID 9649525, Free PMC Article
    4. Conspecific and interspecific interactions between the FEM-2 and the FEM-3 sex-determining proteins despite rapid sequence divergence. Stothard P, et al. J Mol Evol, 2006 Mar. PMID 16477523
    5. CeRep25B forms chromosome-specific minisatellite arrays in Caenorhabditis elegans. Pilgrim D. Genome Res, 1998 Nov. PMID 9847081, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin-dependent protein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in masculinization of hermaphroditic germ-line IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein phosphatase fem-2
    NP_497224.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      632019..634626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064823.10 → NP_497224.1  Protein phosphatase fem-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497224.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49594
      Conserved Domains (1) summary
      pfam00481
      Location:161 → 417
      PP2C; Protein phosphatase 2C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49594.2

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