U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    daf-1 Cell surface receptor daf-1 [ Caenorhabditis elegans ]

    Gene ID: 176829, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    daf-1
    Official Full Name
    Cell surface receptor daf-1
    Primary source
    WormBase:WBGene00000897
    Locus tag
    CELE_F29C4.1
    See related
    AllianceGenome:WB:WBGene00000897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable activin binding activity; activin receptor activity, type I; and transforming growth factor beta receptor activity. Involved in several processes, including dauer entry; determination of adult lifespan; and response to bacterium. Predicted to be located in membrane. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including distal tip cell; ganglia; inner labial sensillum; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; carcinoma (multiple); fibrodysplasia ossificans progressiva; gastrointestinal system cancer (multiple); and glaucoma (multiple). Orthologous to several human genes including ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See daf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (132416..138081)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Cuticle collagen 99;Putative cuticle collagen 99 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Georgi LL, et al. Cell, 1990 May 18. PMID 2160853
    2. Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation. De-Souza EA, et al. Nat Aging, 2023 Aug. PMID 37500972, Free PMC Article
    3. A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Morita K, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11353865, Free PMC Article
    4. Comparative Lipidomics of Caenorhabditis elegans Metabolic Disease Models by SWATH Non-Targeted Tandem Mass Spectrometry. Prasain JK, et al. Metabolites, 2015 Nov 11. PMID 26569325, Free PMC Article
    5. A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Joshua GWP, et al. Microbiology (Reading), 2003 Nov. PMID 14600234

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptomic Profiling of DAF-7/TGFbeta Pathway Mutants in C. elegans.
      Title: Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables activin receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of eating behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cell surface receptor daf-1
    NP_001023159.1
    • Confirmed by transcript evidence
    NP_001023160.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      132416..138081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027988.6 → NP_001023159.1  Cell surface receptor daf-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20792
      Conserved Domains (3) summary
      smart00467
      Location:265 → 293
      GS; GS motif
      cd14056
      Location:297 → 589
      STKc_TGFbR_I; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors
      pfam07714
      Location:293 → 576
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_001027989.6 → NP_001023160.1  Cell surface receptor daf-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20792
      Conserved Domains (3) summary
      smart00467
      Location:265 → 293
      GS; GS motif
      pfam07714
      Location:293 → 575
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:297 → 588
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20792.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous