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    elks-1 ELKS/RAB6-interacting/CAST family member 2 [ Caenorhabditis elegans ]

    Gene ID: 177102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elks-1
    Official Full Name
    ELKS/RAB6-interacting/CAST family member 2
    Primary source
    WormBase:WBGene00018330
    Locus tag
    CELE_F42A6.9
    See related
    AllianceGenome:WB:WBGene00018330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables PDZ domain binding activity. Involved in protein localization and regulation of protein deneddylation. Located in basement membrane and presynaptic active zone. Is expressed in nervous system. Orthologous to several human genes including ERC2 (ELKS/RAB6-interacting/CAST family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elks-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (3342515..3350027, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Dai Y, et al. Nat Neurosci, 2006 Dec. PMID 17115037
    2. Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans. Kittelmann M, et al. J Cell Biol, 2013 Dec 9. PMID 24322429, Free PMC Article
    3. Assembly of synaptic active zones requires phase separation of scaffold molecules. McDonald NA, et al. Nature, 2020 Dec. PMID 33208945
    4. Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. Deken SL, et al. J Neurosci, 2005 Jun 22. PMID 15976086, Free PMC Article
    5. RSY-1 is a local inhibitor of presynaptic assembly in C. elegans. Patel MR, et al. Science, 2009 Mar 13. PMID 19286562, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein ELKS is occasionally transferred by microtubule-based motor neurons of immobilized C. elegans.
      Title: FIONA on Caenorhabditis elegans.
    2. The activity of syd-2(gf) requires elks-1, an ELKS homolog.
      Title: SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.
    3. identify ELKS as a new member of the C. elegans active zone complex, define the role of ELKS in synaptic transmission
      Title: Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ELKS/RAB6-interacting/CAST family member 2
    NP_500329.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3342515..3350027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067928.5 → NP_500329.1  ELKS/RAB6-interacting/CAST family member 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44490
      Conserved Domains (2) summary
      pfam10174
      Location:154 → 781
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam16046
      Location:448 → 545
      FAM76; FAM76 protein
    Nucleotide Protein
    Heading Accession and Version

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