drp-1 Dynamin-1-like protein drp-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: drp-1
Official Full Name: Dynamin-1-like protein drp-1
Primary source: WormBase:WBGene00001093
Locus tag: CELE_T12E12.4
See related: AllianceGenome:WB:WBGene00001093
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in apoptotic mitochondrial changes; embryo development; and mitochondrial fission. Located in mitochondrion. Is expressed in several structures, including germ line; intestine; non-striated muscle; rectal muscle; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See drp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (5538488..5541365)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model.
Title: Selective disruption of Drp1-independent mitophagy and mitolysosome trafficking by an Alzheimer's disease relevant tau modification in a novel Caenorhabditis elegans model.
Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1-dependent process.
Title: Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1-dependent process.
DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants
Title: DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants.
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity
Title: The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
Drp-1 and fis-2 function independent of one another and the Bcl-2 homolog CED-9 and downstream of the CED-3 caspase to promote elimination of mitochondria in dying cells, an event that could facilitate cell-death execution.
Title: Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
DRP-1 mediates mitochondrial fragmentation during EGL-1-induced cell death
Title: DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T12E12.4 (e-PCR)
- UniSTS:310820

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dynamin-1-like protein drp-1

NP_001023375.1

Confirmed by transcript evidence

NP_741403.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5538488..5541365

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171344.6 → NP_741403.2 Dynamin-1-like protein drp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741403.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDY8, Q8WQC9

Conserved Domains (4) summary

cd08771
Location:25 → 304

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:90 → 705

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:229 → 503

Dynamin_M; Dynamin central region

pfam02212
Location:618 → 706

GED; Dynamin GTPase effector domain
NM_001028204.4 → NP_001023375.1 Dynamin-1-like protein drp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023375.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDY8

Conserved Domains (4) summary

cd08771
Location:25 → 304

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:90 → 698

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:229 → 503

Dynamin_M; Dynamin central region

pfam02212
Location:611 → 699

GED; Dynamin GTPase effector domain