kin-18 Serine/threonine-protein kinase SULU [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-18
Official Full Name: Serine/threonine-protein kinase SULU
Primary source: WormBase:WBGene00002201
Locus tag: CELE_T17E9.1
See related: AllianceGenome:WB:WBGene00002201
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in feeding behavior; regulation of meiosis I; and regulation of nematode pharyngeal pumping. Located in cell cortex. Is expressed in several structures, including alimentary muscle; excretory cell; nervous system; pharyngeal-intestinal valve; and rectal gland cell. Orthologous to human TAOK1 (TAO kinase 1); TAOK2 (TAO kinase 2); and TAOK3 (TAO kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kin-18 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (6118620..6124067)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that KIN-18 coordinates meiotic progression by modulating the timing of MPK-1 activation and the progression of recombination events
Title: Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.
Title: The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T17E9.1 (e-PCR)
- UniSTS:310872

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase SULU

NP_001022767.1

Confirmed by transcript evidence

NP_001367437.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6118620..6124067

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379744.1 → NP_001367437.1 Serine/threonine-protein kinase SULU [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

pfam17380
Location:672 → 951

DUF5401; Family of unknown function (DUF5401)

cl21453
Location:28 → 291

PKc_like; Protein Kinases, catalytic domain
NM_001027596.5 → NP_001022767.1 Serine/threonine-protein kinase SULU [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022767.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P46549, Q8MPX1

Conserved Domains (2) summary

smart00220
Location:30 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:28 → 291

PKc_like; Protein Kinases, catalytic domain