M57.2 Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: M57.2
Official Full Name: Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II
Primary source: WormBase:WBGene00019778
Locus tag: CELE_M57.2
See related: AllianceGenome:WB:WBGene00019778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein prenyltransferase activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See M57.2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (3527354..3532473)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Rab geranylgeranyl transferase by farnesyl transferase inhibitors or RNA interference, induced apoptotis in germ line cells.
Title: Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M57.2 (e-PCR)
- UniSTS:312703

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to Rab geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rab geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in prenylation	IEA Inferred from Electronic Annotation more info
involved_in protein prenylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Geranylgeranyl transferase type-2 subunit alpha;Protein geranylgeranyltransferase type II

NP_001368209.1

Confirmed by transcript evidence

NP_500367.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3527354..3532473

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067966.5 → NP_500367.1 Geranylgeranyl transferase type-2 subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500367.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TYY0

Conserved Domains (6) summary

COG4886
Location:405 → 550

LRR; Leucine-rich repeat (LRR) protein [Transcription]

COG5536
Location:37 → 264

BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]

sd00031
Location:501 → 522

LRR_1; leucine-rich repeat [structural motif]

sd00006
Location:123 → 153

TPR; TPR repeat [structural motif]

pfam01239
Location:179 → 206

PPTA; Protein prenyltransferase alpha subunit repeat

pfam12799
Location:499 → 539

LRR_4; Leucine Rich repeats (2 copies)
NM_001380149.1 → NP_001368209.1 Protein geranylgeranyltransferase type II [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PB59