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    hsd-2 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hsd-2
    Official Full Name
    3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
    Primary source
    WormBase:WBGene00022498
    Locus tag
    CELE_ZC8.1
    See related
    AllianceGenome:WB:WBGene00022498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Predicted to be located in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to several human genes including SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hsd-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (5005240..5007037)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-kinase type 2 Neighboring gene Rootletin-like coiled-coil domain-containing protein Neighboring gene ncRNA Neighboring gene MYND-type domain-containing protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein Neighboring gene SCP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus. Carstensen HR, et al. Genetics, 2021 Jun 24. PMID 33963848, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein
    NP_508851.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5005240..5007037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076450.7 → NP_508851.1  3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23086
      Conserved Domains (1) summary
      cl21454
      Location:5 → 327
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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