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    pash-1 DRBM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pash-1
    Official Full Name
    DRBM domain-containing protein
    Primary source
    WormBase:WBGene00011908
    Locus tag
    CELE_T22A3.5
    See related
    AllianceGenome:WB:WBGene00011908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in several processes, including primary miRNA processing; regulation of epidermal cell differentiation; and regulation of vulval development. Predicted to be part of microprocessor complex. Is expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pash-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (10598673..10606621)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-18 Neighboring gene ncRNA Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene Kringle domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene Laminin subunit alpha lam-3 Neighboring gene Repressor of RNA polymerase III transcription MAF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-mount in situ hybridization method for microRNA detection in Caenorhabditis elegans. Andachi Y, et al. RNA, 2016 Jul. PMID 27154969, Free PMC Article
    2. Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans. Lehrbach NJ, et al. RNA, 2012 Dec. PMID 23097426, Free PMC Article
    3. Dissection of the Caenorhabditis elegans Microprocessor. Nguyen TL, et al. Nucleic Acids Res, 2023 Feb 28. PMID 36598924, Free PMC Article
    4. Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans. Rios C, et al. Dev Biol, 2017 Jun 1. PMID 28461238, Free PMC Article
    5. Tissue-specific overexpression of systemic RNA interference components limits lifespan in C. elegans. Camara H, et al. Gene, 2024 Feb 15. PMID 37984536

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conditional loss of pash-1 activity resulted in a reduced rate of ovulation and in basal and ovulatory sheath contractions.
      Title: Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans.
    2. role for pash-1 in miRNA maturation and miRNA-mediated gene regulation.
      Title: Processing of primary microRNAs by the Microprocessor complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of microprocessor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of microprocessor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DRBM domain-containing protein
    NP_001293461.1
    • Confirmed by transcript evidence
    NP_001293462.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10598673..10606621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306532.2 → NP_001293461.1  DRBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRH5
      Conserved Domains (2) summary
      smart00456
      Location:175 → 205
      WW; Domain with 2 conserved Trp (W) residues
      pfam00035
      Location:449 → 472
      dsrm; Double-stranded RNA binding motif

    2. NM_001306533.3 → NP_001293462.1  DRBM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEM4
    Nucleotide Protein
    Heading Accession and Version

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