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    W10C8.4 GST C-terminal domain-containing protein;Glutathione S-transferase [ Caenorhabditis elegans ]

    Gene ID: 189332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    W10C8.4
    Official Full Name
    GST C-terminal domain-containing protein;Glutathione S-transferase
    Primary source
    WormBase:WBGene00021127
    Locus tag
    CELE_W10C8.4
    See related
    AllianceGenome:WB:WBGene00021127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See W10C8.4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (2851957..2853903, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SH3 domain-containing protein Neighboring gene arginine kinase Neighboring gene ncRNA Neighboring gene Plasma membrane proteolipid 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GST C-terminal domain-containing protein;Glutathione S-transferase
    NP_001300446.1
    • Confirmed by transcript evidence
    NP_001300447.1
    • Confirmed by transcript evidence
    NP_491056.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2851957..2853903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058655.6 → NP_491056.2  Glutathione S-transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491056.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45010
      Conserved Domains (3) summary
      PTZ00057
      Location:14 → 210
      PTZ00057; glutathione s-transferase; Provisional
      cl00388
      Location:9 → 79
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:133 → 205
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001313517.3 → NP_001300446.1  GST C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUA9
      Conserved Domains (2) summary
      COG0625
      Location:9 → 155
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl02776
      Location:86 → 158
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. NM_001313518.3 → NP_001300447.1  GST C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWN2
      Conserved Domains (1) summary
      cl02776
      Location:23 → 99
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version

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