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    • Showing Current items.

    npp-4 Nucleoporin p58/p45 [ Caenorhabditis elegans ]

    Gene ID: 173329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-4
    Official Full Name
    Nucleoporin p58/p45
    Primary source
    WormBase:WBGene00003790
    Locus tag
    CELE_Y54E5A.4
    See related
    AllianceGenome:WB:WBGene00003790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Involved in several processes, including determination of adult lifespan; establishment of mitotic spindle orientation; and nucleus organization. Predicted to be part of nuclear pore central transport channel. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (14701122..14706522, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Putative sphingolipid delta(4)-desaturase/C4-monooxygenase Neighboring gene Recep_L_domain domain-containing protein Neighboring gene Polysaccharide biosynthesis domain-containing protein Neighboring gene DRBM domain-containing protein Neighboring gene B30.2/SPRY domain-containing protein;CTLH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, et al. Dev Cell, 2017 Oct 23. PMID 29065307, Free PMC Article
    2. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter A, et al. Dev Biol, 2006 Jan 15. PMID 16325795, Free PMC Article
    3. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article
    4. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. D'Angelo MA, et al. Cell, 2009 Jan 23. PMID 19167330, Free PMC Article
    5. A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Vastenhouw NL, et al. Curr Biol, 2003 Aug 5. PMID 12906791

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nucleoporin p58/p45
    NP_493552.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14701122..14706522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061151.6 → NP_493552.1  Nucleoporin p58/p45 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWK3
      Conserved Domains (1) summary
      pfam13634
      Location:21 → 122
      Nucleoporin_FG; Nucleoporin FG repeat region
    Nucleotide Protein
    Heading Accession and Version

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