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    cox-10 Heme O synthase [ Caenorhabditis elegans ]

    Gene ID: 174899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cox-10
    Official Full Name
    Heme O synthase
    Primary source
    WormBase:WBGene00012895
    Locus tag
    CELE_Y46G5A.2
    See related
    AllianceGenome:WB:WBGene00012895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protoheme IX farnesyltransferase activity. Predicted to be involved in heme A biosynthetic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cox-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (12679954..12686765)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Complex I-B12 Neighboring gene Nodule Cysteine-Rich (NCR) secreted peptide Neighboring gene ncRNA Neighboring gene CRC domain-containing protein;Rab-GAP TBC domain-containing protein Neighboring gene U5 small nuclear ribonucleoprotein 200 kDa helicase Neighboring gene ncRNA Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protoheme IX farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protoheme IX farnesyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Heme O synthase
    NP_496708.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12679954..12686765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064307.7 → NP_496708.2  Heme O synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496708.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ES01
      Conserved Domains (1) summary
      cd13957
      Location:93 → 351
      PT_UbiA_Cox10; Protoheme IX farnesyltransferase
    Nucleotide Protein
    Heading Accession and Version

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