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    lron-8 LRRCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lron-8
    Official Full Name
    LRRCT domain-containing protein
    Primary source
    WormBase:WBGene00020693
    Locus tag
    CELE_T22E7.1
    See related
    AllianceGenome:WB:WBGene00020693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in body wall musculature; hypodermis; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64; congenital stationary night blindness 1A; glaucoma; and night blindness. Orthologous to several human genes including LINGO1 (leucine rich repeat and Ig domain containing 1); LINGO2 (leucine rich repeat and Ig domain containing 2); and LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lron-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (5768919..5773627)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Palmitoyltransferase Neighboring gene Histone H1.5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LRRCT domain-containing protein
    NP_491676.2
    • Confirmed by transcript evidence
    NP_740857.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5768919..5773627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059275.6 → NP_491676.2  LRRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491676.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5D7
      Conserved Domains (3) summary
      smart00082
      Location:235 → 282
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:71 → 237
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:75 → 98
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_170869.8 → NP_740857.2  LRRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740857.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S81
      Conserved Domains (3) summary
      smart00082
      Location:235 → 282
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:71 → 237
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:75 → 98
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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