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    sws-1 SWIM-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189734, updated on 27-Dec-2024

    Summary

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    Official Symbol
    sws-1
    Official Full Name
    SWIM-type domain-containing protein
    Primary source
    WormBase:WBGene00012698
    Locus tag
    CELE_Y39B6A.40
    See related
    AllianceGenome:WB:WBGene00012698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure 71. Orthologous to human ZSWIM7 (zinc finger SWIM-type containing 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sws-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (18979319..18981479, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein Neighboring gene REPS (RalBP1-associated Eps domain-containing protein) homolog Neighboring gene Structural protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR Technology Reveals RAD(51)-ical Mechanisms of Repair in Roundworms: An Educational Primer for Use with "Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans". Turcotte CA, et al. Genetics, 2016 Nov. PMID 28114101, Free PMC Article
    2. Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans. McClendon TB, et al. Genetics, 2016 May. PMID 26936927, Free PMC Article
    3. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Shu complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SWIM-type domain-containing protein
    NP_001300234.1
    • Confirmed by transcript evidence
    NP_001300235.1
    • Confirmed by transcript evidence
    NP_001380187.1
    • Confirmed by transcript evidence
    NP_741657.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18979319..18981479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313305.2 → NP_001300234.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AY91

    2. NM_171567.4 → NP_741657.2  SWIM-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741657.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MYM5

    3. NM_001392693.1 → NP_001380187.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV98

    4. NM_001313306.1 → NP_001300235.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT01
    Nucleotide Protein
    Heading Accession and Version

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