mlst-8 Target of rapamycin complex subunit lst8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mlst-8
Official Full Name: Target of rapamycin complex subunit lst8
Primary source: WormBase:WBGene00015697
Locus tag: CELE_C10H11.8
See related: AllianceGenome:WB:WBGene00015697
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in mesendoderm development. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mlst-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (4735251..4738102, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C10H11.8 (e-PCR)
- UniSTS:308535

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesendoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Target of rapamycin complex subunit lst8

NP_001249708.1

Confirmed by transcript evidence

NP_001249709.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4735251..4738102 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001262780.3 → NP_001249709.1 Target of rapamycin complex subunit lst8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001249709.1

Status: REVIEWED

UniProtKB/TrEMBL

P91040

Conserved Domains (2) summary

sd00039
Location:46 → 79

7WD40; WD40 repeat [structural motif]

cl29593
Location:46 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001262779.3 → NP_001249708.1 Target of rapamycin complex subunit lst8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001249708.1

Status: REVIEWED

UniProtKB/TrEMBL

E5QCF5

Conserved Domains (2) summary

sd00039
Location:20 → 53

7WD40; WD40 repeat [structural motif]

cl29593
Location:20 → 327

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...