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    txdc-12.2 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    txdc-12.2
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00018656
    Locus tag
    CELE_F49H12.5
    See related
    AllianceGenome:WB:WBGene00018656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be active in endoplasmic reticulum. Orthologous to several human genes including TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See txdc-12.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (2074450..2075944)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Exostosin domain-containing protein Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin domain-containing protein
    NP_508381.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2074450..2075944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075980.8 → NP_508381.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5S7
      Conserved Domains (1) summary
      cd02959
      Location:32 → 150
      ERp19; Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that ...
    Nucleotide Protein
    Heading Accession and Version

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